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Vitamin D3 Receptor (Phospho-Ser51) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Vitamin D3 Receptor (Phospho-Ser51) Antibody AP52537
    Western blot analysis of extracts from COLO cells, treated with Insulin (0.01U/ml, 15mins), using Vitamin D3 Receptor (Phospho-Ser51) antibody.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P11473
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 48289 Da
Additional Information
Gene ID 7421
Other Names Vitamin D3 receptor, VDR, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name VDR
Synonyms NR1I1
Function Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

References

Baker A.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).
Goto H.,et al.Biochim. Biophys. Acta 1132:103-108(1992).
Rae J.L.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Miyamoto K.,et al.Mol. Endocrinol. 11:1165-1179(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 295.00
Cat# AP52537
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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