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FRS2 (Phospho-Tyr436) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FRS2 (Phospho-Tyr436) Antibody AP52549
    Western blot analysis of extracts from COS cells, using FRS2 (Phospho-Tyr436) antibody.
  • WB - FRS2 (Phospho-Tyr436) Antibody AP52549
    Western blot analysis of extracts from HuvEc cells (Lane 2) and JK cells (Lane 3), using FRS2 (Phospho-Tyr436) Antibody. The lane on the left is treated with synthesized peptide.
  • IHC - FRS2 (Phospho-Tyr436) Antibody AP52549
    Immunohistochemistry analysis of paraffin-embedded human brain tissue using FRS2 (Phospho-Tyr436) antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q8WU20
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 57029 Da
Additional Information
Gene ID 10818
Other Names Fibroblast growth factor receptor substrate 2, FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1, FRS2
Dilution WB~~1:1000
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name FRS2
Function Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Cellular Location Endomembrane system. Note=Cytoplasmic, membrane-bound
Tissue Location Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis
Research Areas
Citations (0)

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Background

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

References

Xu H.,et al.J. Biol. Chem. 273:17987-17990(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Meakin S.O.,et al.J. Biol. Chem. 274:9861-9870(1999).

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$ 295.00
Cat# AP52549
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
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