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Cyclin C (Phospho-Ser275) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Cyclin C (Phospho-Ser275) Antibody AP52581
    Western blot analysis of extracts from 3T3 cells, treated with UV (15mins), using Cyclin C (Phospho-Ser275) antibody.
  • WB - Cyclin C (Phospho-Ser275) Antibody AP52581
    Western blot analysis of extracts from 3T3 cells (Lane 2), A549 cells (Lane 3) and Hela cells (Lane 4), using Cyclin C (Phospho-Ser275) Antibody. The lane on the left is treated with synthesized peptide.
  • IHC - Cyclin C (Phospho-Ser275) Antibody AP52581
    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Cyclin C (Phospho-Ser275) antibody
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P24863
Host Rabbit
Clonality Polyclonal
Calculated MW 33243 Da
Additional Information
Gene ID 892
Other Names Cyclin-C, SRB11 homolog, hSRB11, CCNC
Dilution WB~~1:1000
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name CCNC
Function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Cellular Location Nucleus.
Tissue Location Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain
Research Areas
Citations (0)

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Background

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

References

Lew D.J.,et al.Cell 66:1197-1206(1991).
Li H.,et al.Genomics 32:253-259(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Rickert P.,et al.Oncogene 12:2631-2640(1996).

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$ 295.00
Cat# AP52581
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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