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EPS15 (Phospho-Tyr849) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - EPS15 (Phospho-Tyr849) Antibody AP52584
    Western blot analysis of extracts from HepG2 cells, using EPS15 (Phospho-Tyr849) antibody.
  • WB - EPS15 (Phospho-Tyr849) Antibody AP52584
    Western blot analysis of extracts from JK cells (Lane 2), using EPS15 (Phospho-Tyr849) Antibody. The lane on the left is treated with synthesized peptide.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P42566
Host Rabbit
Clonality Polyclonal
Calculated MW 98656 Da
Additional Information
Gene ID 2060
Other Names Epidermal growth factor receptor substrate 15, Protein Eps15, Protein AF-1p, EPS15, AF1P
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name EPS15
Synonyms AF1P
Function Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Background

Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

References

Wong W.T.,et al.Oncogene 9:1591-1597(1994).
Bernard O.A.,et al.Oncogene 9:1039-1045(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kronstein R.,et al.Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 295.00
Cat# AP52584
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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