|Calculated MW||165763 Da|
|Other Names||Nuclear factor of activated T-cells 5, NF-AT5, T-cell transcription factor NFAT5, Tonicity-responsive enhancer-binding protein, TonE-binding protein, TonEBP, NFAT5, KIAA0827, TONEBP|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.|
|Cellular Location||Nucleus. Cytoplasm. Note=Nuclear distribution increases under hypertonic conditions|
|Tissue Location||Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.
Lopez-Rodriguez C.,et al.Cold Spring Harb. Symp. Quant. Biol. 64:517-526(1999).
Miyakawa H.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:2538-2542(1999).
Lopez-Rodriguez C.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:7214-7219(1999).
Dalski A.,et al.Cytogenet. Cell Genet. 93:239-241(2001).
Nagase T.,et al.DNA Res. 5:355-364(1998).
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