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RNASEK Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q6P5S7 |
| Other Accession | Q8K3C0, Q3ZC23 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15420 Da |
| Antigen Region | 26-55 aa |
| Gene ID | 440400 |
|---|---|
| Other Names | Ribonuclease kappa, RNase K, RNase kappa, 31--, RNASEK |
| Target/Specificity | This RNASEK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the Central region of human RNASEK. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNASEK Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RNASEK |
|---|---|
| Function | Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate (PubMed:17881363). Regulates the activity of vacuolar (H+)-ATPase (V- ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:26212330). Required at an early stage of receptor-mediated endocytosis (PubMed:26212330). |
| Cellular Location | Endomembrane system; Multi-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q3ZC23}; Multi-pass membrane protein |
| Tissue Location | Widely expressed.. |
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
RNASEK is endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. RNASEK hydrolyzes UpU bonds at a lower rate.
References
Economopoulou, M.A., et al. Nucleic Acids Res. 35(19):6389-6398(2007)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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$ 365.00
$ 140.00
Cat# AP5259c
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