|Application ||WB, IHC|
|Calculated MW||38243 Da|
|Other Names||Nuclear migration protein nudC, Nuclear distribution protein C homolog, NUDC|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern|
|Tissue Location||Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.|
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Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
Miller B.A.,et al.Exp. Hematol. 27:742-750(1999).
Matsumoto N.,et al.Hum. Genet. 104:498-504(1999).
Song H.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Yamamoto T.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Li N.G.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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