|Calculated MW||124184 Da|
|Other Names||Phospholipase D1, PLD 1, hPLD1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, PLD1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Late endosome membrane; Lipid- anchor; Cytoplasmic side|
|Tissue Location||Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.|
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Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Hammond S.M.,et al.J. Biol. Chem. 270:29640-29643(1995).
Hammond S.M.,et al.J. Biol. Chem. 272:3860-3868(1997).
Steed P.M.,et al.FASEB J. 12:1309-1317(1998).
Hughes W.E.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Lopez I.,et al.J. Biol. Chem. 273:12846-12852(1998).
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