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BCL2 (Phospho-Ser70) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BCL2 (Phospho-Ser70) Antibody AP52614
    Western blot analysis of extracts from 293 cells. Jurkat cells and NIH/3T3 cells all treated with Paclitaxel, using BCL2 (Phospho-Ser70) antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P10415
Host Rabbit
Clonality Polyclonal
Calculated MW 26266 Da
Additional Information
Gene ID 596
Other Names Apoptosis regulator Bcl-2, BCL2
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name BCL2
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
Tissue Location Expressed in a variety of tissues.
Research Areas
Citations (0)

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Background

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

References

Tsujimoto Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5214-5218(1986).
Eguchi Y.,et al.Nucleic Acids Res. 20:4187-4192(1992).
Cleary M.L.,et al.Cell 47:19-28(1986).
Seto M.,et al.EMBO J. 7:123-131(1988).
Hua C.,et al.Oncogene Res. 2:263-275(1988).

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$ 295.00
Cat# AP52614
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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