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FADD (Phospho-Ser191) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FADD (Phospho-Ser191) Antibody AP52615
    Western blot analysis of extracts from Jurkat cells, treated with PMA (125ng/ml, 30mins), using FADD (Phospho-Ser191) antibody.
  • IHC - FADD (Phospho-Ser191) Antibody AP52615
    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using FADD (Phospho-Ser191) antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q61160
Other Accession Q13158
Host Rabbit
Clonality Polyclonal
Calculated MW 22960 Da
Additional Information
Gene ID 14082
Other Names FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Protein FADD, Fadd, Mort1
Dilution WB~~1:1000
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name Fadd
Synonyms Mort1
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).
Research Areas
Citations (0)

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Background

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).

References

Zhang J.,et al.Mol. Cell. Biol. 16:2756-2763(1996).
Hsu H.,et al.Cell 84:299-308(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Jeong E.-J.,et al.J. Biol. Chem. 274:16337-16342(1999).

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$ 295.00
Cat# AP52615
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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