|Application ||IHC-P, FC, WB, E|
|Calculated MW||28315 Da|
|Antigen Region||190-218 aa|
|Other Names||R-spondin-2, Roof plate-specific spondin-2, hRspo2, RSPO2|
|Target/Specificity||This RSPO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-218 amino acids from the C-terminal region of human RSPO2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||RSPO2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.|
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Provided below are standard protocols that you may find useful for product applications.
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling.
Kim, K.A., et al. Cell Cycle 5(1):23-26(2006)
Kazanskaya, O., et al. Dev. Cell 7(4):525-534(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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