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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EpCAM Antibody   

EpCAM Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - EpCAM Antibody AP52678
    Western blot analysis of extracts from CHO-K1 cells,transfected with a human pDisplay-flag construct (A) or transfected with a human pDisplay-flag-EpCAM construct (B), using EpCAM mouse mAb (1:1000 diluted).Predicted band size:40KDa.Observed band size:40KDa.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P16422
Host Mouse
Clonality Monoclonal
Calculated MW 40 KDa
Additional Information
Gene ID 4072
Other Names 17 1A;323/A3;Adenocarcinoma associated antigen;Adenocarcinoma-associated antigen;Antigen identified by monoclonal; AUA1;AUA1;CD326;CD326 antigen;Cell surface glycoprotein Trop 1;Cell surface glycoprotein Trop-1;CO 17A;CO17 1A;CO17A;DIAR5;EGP 2;EGP;EGP2;EGP314; EGP40;Ep CAM;Ep-CAM;EPCAM;EPCAM_HUMAN;Epithelial cell adhesion molecule;Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD);Epithelial cell surface antigen; Epithelial cellular adhesion molecule;Epithelial glycoprotein 314;Epithelial glycoprotein;ESA;GA733 2;GA733-2;hEGP 2;hEGP314;HNPCC8;Human epithelial glycoprotein 2;KS 1/4 antigen;KS1/4;KSA;Lymphocyte antigen 74;M1S2;M4S1;Major gastrointestinal tumor associated protein GA733 2;Major gastrointestinal tumor-associated protein GA733-2;Membrane component chromosome 4 surface marker (35kD glycoprotein);Membrane component, chromosome 4, surface marker;MIC18;MK 1;TACD1;TACSTD1;TROP1;Tumor associated calcium signal transducer 1;Tumor-associated calcium signal transducer 1.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name EPCAM
Synonyms GA733-2, M1S2, M4S1, MIC18, TACSTD1, TRO
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Cellular Location Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction
Tissue Location Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Research Areas
Citations (0)

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Background

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

References

Strnad J.,et al.Cancer Res. 49:314-317(1989).
Perez M.S.,et al.J. Immunol. 142:3662-3667(1989).
Simon B.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990).
Szala S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:3542-3546(1990).
Linnenbach A.J.,et al.Mol. Cell. Biol. 13:1507-1515(1993).

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$ 295.00
Cat# AP52678
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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