|Calculated MW||190 KDa|
|Other Names||ACE 1;ACE;ACE T;ACE_HUMAN;ACE1;Angiotensin converting enzyme somatic isoform;Angiotensin converting enzyme testis specific isoform;Angiotensin I converting enzyme;Angiotensin I converting enzyme 1;Angiotensin I converting enzyme peptidyl dipeptidase A 1; Angiotensin-converting enzyme;Carboxycathepsin;CD 143;CD143;CD143 antigen;DCP 1;DCP; DCP1;Dipeptidyl carboxypeptidase 1;Dipeptidyl carboxypeptidase I;Kininase II;MGC26566; MVCD3;Peptidase P;Peptidyl dipeptidase A;soluble form;Testicular ECA.|
|Format||Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.|
|Cellular Location||Angiotensin-converting enzyme, soluble form: Secreted|
|Tissue Location||Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis|
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Provided below are standard protocols that you may find useful for product applications.
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Soubrier F.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:9386-9390(1988).
Lattion A.L.,et al.FEBS Lett. 252:99-104(1989).
Ehlers M.R.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:7741-7745(1989).
Rieder M.J.,et al.Nat. Genet. 22:59-62(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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