|Application ||WB, ICC|
|Calculated MW||46 KDa|
|Other Names||Cell proliferation inducing gene 46 protein;Cell proliferation inducing protein 46;Cell proliferation-inducing gene 46 protein;CK 18;CK-18;CK18;Cytokeratin 18;Cytokeratin endo B;Cytokeratin-18;Cytokeratin18;K 18;K18;K1C18_HUMAN;Keratin 18;Keratin D;Keratin type I cytoskeletal 18;keratin, type I cytoskeletal 18;Keratin-18;Keratin18;Kerd;KRT18.|
|Format||Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus, nucleolus|
|Tissue Location||Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.|
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Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Oshima R.G.,et al.Differentiation 33:61-68(1986).
Kim J.W.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kulesh D.A.,et al.Mol. Cell. Biol. 8:1540-1550(1988).
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