|Application ||WB, IHC-P, FC, E|
|Calculated MW||10679 Da|
|Antigen Region||46-75 aa|
|Other Names||Small cell adhesion glycoprotein, Small transmembrane and glycosylated protein, SMAGP|
|Target/Specificity||This SMAGP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the Central region of human SMAGP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SMAGP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions (PubMed:15021913). Detected on cytoplasmic membranes in undifferentiated tumors (PubMed:15986429)|
|Tissue Location||Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
SMAGP may play a role in epithelial cell-cell contacts. SMAGP may play a role in tumor invasiveness and metastasis formation.
Tarbe, N.G., et al. Int. J. Cancer 117(6):913-922(2005)
Tarbe, N.G., et al. Oncogene 23(19):3395-3403(2004)
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