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GRK2 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P25098 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 80 KDa |
| Gene ID | 156 |
|---|---|
| Other Names | ADRBK 1;ADRBK1;Adrenergic beta receptor kinase 1;Adrenergic beta receptor kinase 1; ARBK1_HUMAN;BARK 1;BARK;BARK1;Beta adrenergic receptor kinase 1;Beta ARK 1;Beta ARK1; Beta-adrenergic receptor kinase 1;Beta-ARK-1;FLJ16718;G Protein Coupled Receptor Kinase 2;G protein dependent receptor kinase 2;G-protein coupled receptor kinase 2;GRK 2;GRK2. |
| Dilution | WB~~1:500 |
| Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide, 50%,glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | GRK2 (HGNC:289) |
|---|---|
| Synonyms | ADRBK1, BARK, BARK1 |
| Function | Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378). Key regulator of LPAR1 signaling (PubMed:19306925). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925). Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner (PubMed:19306925). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P26817}. Cell membrane {ECO:0000250|UniProtKB:P21146}. Postsynapse {ECO:0000250|UniProtKB:P26817}. Presynapse {ECO:0000250|UniProtKB:P26817} |
| Tissue Location | Expressed in peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
References
Benovic J.L.,et al.FEBS Lett. 283:122-126(1991).
Chuang T.T.,et al.J. Biol. Chem. 267:6886-6892(1992).
Penn R.B.,et al.J. Biol. Chem. 269:14924-14930(1994).
Aragay A.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998).
Oppermann M.,et al.J. Biol. Chem. 274:8875-8885(1999).
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