|Calculated MW||110 KDa|
|Other Names||Heterogeneous nuclear ribonucleoprotein U;hnRNP U protein;HNRNPU;hnRNPU protein;HNRPU; HNRPU_HUMAN;p120;p120 nuclear protein;SAF A;SAF-A;SAFA;Scaffold attachment factor A;U21.1.|
|Format||Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50% glycerol|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Synonyms||HNRPU, SAFA, U21.1|
|Function||Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Cell surface. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes.|
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Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity).
Kiledjian M.,et al.EMBO J. 11:2655-2664(1992).
Fackelmayer F.O.,et al.Biochim. Biophys. Acta 1217:232-234(1994).
Fackelmayer F.O.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Jordan P.,et al.Biochemistry 33:14696-14706(1994).
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