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PRMT1 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - PRMT1 Antibody AP52749
    Western blot detection of PRMT1 in Hela,A549 and SW480 cell lysates using PRMT1 mouse mAb (1:1000 diluted).Predicted band size:42KDa.Observed band size:42KDa.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q99873
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Calculated MW 42 KDa
Additional Information
Gene ID 3276
Other Names ANM 1;ANM1;ANM1_HUMAN;complete cds;HCP 1;HCP1;Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2;Heterogeneous nuclear ribonucleoproteins methyltransferase like 2;Heterogeneous nuclear ribonucleoproteins methyltransferase like2;Histone-arginine N-methyltransferase PRMT1;HMT 2;HMT1 (hnRNP methyltransferase;HMT1 (hnRNP methyltransferase S. cerevisiae) like 2;HMT1 hnRNP methyltransferase;HMT1 hnRNP methyltransferase like 2 (S. cerevisiae);HMT1 hnRNP methyltransferase like 2;HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae);HMT2;HRMT1 L2;HRMT1L 2;HRMT1L2;Human mRNA for suppressor for yeast mutant;Human mRNA for suppressor for yeast mutant complete cds;Interferon receptor 1 bound protein 4;Interferon receptor 1 bound protein4;Interferon receptor 1-bound protein 4;Interferon receptor 1bound protein 4;IR1 B4;IR1B 4;IR1B4;Mrmt 1;Mrmt1;PRMT 1;PRMT1;Protein arginine methyltransferase 1;Protein arginine N methyltransferase 1;Protein arginine N methyltransferase1;Protein arginine N-methyltransferase 1;R1B4;S. cerevisiae like 2.
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PRMT1
Synonyms HMT2, HRMT1L2, IR1B4
Function Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).
Cellular Location Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity).
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity.

References

Scott H.S.,et al.Genomics 48:330-340(1998).
Nikawa J.,et al.Gene 171:107-111(1996).
Scorilas A.,et al.Biochem. Biophys. Res. Commun. 278:349-359(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
Cat# AP52749
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
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