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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PKM2 Antibody   

PKM2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - PKM2 Antibody AP52752
    Western blot detection of PKM2 in HCT116,COS7,K562,A549 and Hela cell lysates using PKM2 mouse mAb (1:1000 diluted).Predicted band size:60KDa.Observed band size:60KDa.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P14618
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Calculated MW 60 KDa
Additional Information
Gene ID 5315
Other Names CTHBP ;Cytosolic thyroid hormone binding protein ;Cytosolic thyroid hormone-binding protein ;KPYM_HUMAN ;MGC3932 ;OIP 3 ;OIP-3 ;OIP3 ;OPA interacting protein 3 ;Opa-interacting protein 3 ;p58 ;PK muscle type ;PK, muscle type ;PK2 ;PK3 ;PKM ;PKM2 ;pykm ;Pyruvate kinase 2/3 ;Pyruvate kinase 3 ;Pyruvate kinase isozymes M1/M2 ;Pyruvate kinase muscle ;Pyruvate kinase muscle isozyme ;pyruvate kinase PKM ;Pyruvate kinase, muscle 2 ;TCB ;THBP1 ;Thyroid hormone binding protein 1 ;Thyroid hormone binding protein cytosolic ;Thyroid hormone-binding protein 1 ;Tumor M2 PK ;Tumor M2-PK .
Dilution WB~~1:1000
Format PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PKM
Synonyms OIP3, PK2, PK3, PKM2
Function Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity
Tissue Location Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.
Research Areas
Citations (0)

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Background

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

References

Tani K.,et al.Gene 73:509-516(1988).
Kato H.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:7861-7865(1989).
Kato H.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:1625-1625(1990).
Takenaka M.,et al.Eur. J. Biochem. 198:101-106(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 295.00
Cat# AP52752
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
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