|Calculated MW||56 KDa|
|Other Names||mitochondrial;selenoprotein Z;SELZ;Thioredoxin reductase 2;Thioredoxin reductase 2 mitochondrial;thioredoxin reductase 3;thioredoxin reductase beta;Thioredoxin reductase TR3;TR 3;TR;TR beta;TR-beta;TRXR 2;TRXR2;TRXR2_HUMAN;TXNRD 2;Txnrd2.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.|
|Tissue Location||Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690)|
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Provided below are standard protocols that you may find useful for product applications.
Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling.
Sun Q.-A.,et al.J. Biol. Chem. 274:24522-24530(1999).
Gasdaska P.Y.,et al.FEBS Lett. 442:105-111(1999).
Miranda-Vizuete A.,et al.Eur. J. Biochem. 261:405-412(1999).
Toji S.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Lescure A.,et al.J. Biol. Chem. 274:38147-38154(1999).
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