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SMARCC1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q92922 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 155 KDa |
| Gene ID | 6599 |
|---|---|
| Other Names | AI115498;BAF 155;BAF155;BRG 1 associated factor 155;BRG1 associated factor 155;BRG1-associated factor 155;Chromatin remodeling complex BAF155 subunit;CRACC 1;CRACC1; Mammalian chromatin remodeling complex BRG 1 associated factor 155;Mammalian chromatin remodeling complex BRG1 associated factor 155;Rsc 8;Rsc8;SMARC C1;SMARCC 1;SMARCC1; SMRC1_HUMAN;SRG 3;SRG3;SWI 3;SWI/SNF complex 155 kDa subunit;SWI/SNF related matrix associated actin dependent regulator of chromatin c1;SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1;SWI3. |
| Dilution | WB~~1:1000 |
| Format | Purified mouse monoclonal in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SMARCC1 (HGNC:11104) |
|---|---|
| Synonyms | BAF155 |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas |
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Background
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
References
Wang W.,et al.Genes Dev. 10:2117-2130(1996).
Bienvenut W.V.,et al.Submitted (JUL-2007) to UniProtKB.
Sif S.,et al.Genes Dev. 12:2842-2851(1998).
Kitagawa H.,et al.Cell 113:905-917(2003).
Brill L.M.,et al.Anal. Chem. 76:2763-2772(2004).
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