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CDX2 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • IP - CDX2 Antibody AP52774
    Immunoprecipitation analysis of Hela cell lysate using CDX2 mouse mAb.
    detail
  • WB - CDX2 Antibody AP52774
    Western blot detection of CDX2 in Hela,Caco2,C2C12,SW480,COS7,HepG2 and 3T3 cell lysates using CDX2 mouse mAb (1:1000 diluted).Predicted band size:34KDa.Observed band size:34KDa.
    detail
  • ICC - CDX2 Antibody AP52774
    Immunocytochemistry stain of Hela using CDX2 mouse mAb (1:100).
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, ICC, IP
Primary Accession Q99626
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype lgG2b
Calculated MW 34 KDa
Additional Information
Gene ID 1045
Other Names Caudal type homeo box 2;Caudal type homeo box transcription factor 2;Caudal type homeobox 2;Caudal type homeobox protein 2;caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2;CDX 2;CDX 3;CDX-3;Cdx2;CDX2_HUMAN;CDX3;Homeobox protein CDX 2;Homeobox protein CDX-2;Homeobox protein CDX2.
Dilution IP~~1:500
WB~~1:1000
ICC~~1:100
Format Purified mouse monoclonal in PBS(pH 7.4)containing with 0.09% (W/V) sodium azide,50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CDX2
Synonyms CDX3
Function Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P43241}.
Tissue Location Detected in small intestine, colon and pancreas.
Research Areas
Citations (0)
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Background

Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine.

References

Drummond F.J.,et al.Ann. Hum. Genet. 61:393-400(1997).
Mallo G.V.,et al.Int. J. Cancer 74:35-44(1997).
Sivagnanasundaram S.,et al.Br. J. Cancer 84:218-225(2001).
Tanizawa Y.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).

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$ 360.00
Cat# AP52774
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