|Calculated MW||72 KDa|
|Other Names||alpha pal;alpha palindromic binding protein;Alpha palindromic-binding protein;Alpha-pal; locus control region factor 1;NFE2 related factor 1;NRF-1;Nrf1;NRF1_HUMAN;Nuclear respiratory factor 1;transcription factor 11.|
|Format||Purified mouse monoclonal in PBS(pH 7.4)containing with 0.02% sodium azide,50% glycerol,0.1%BSA.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.|
|Tissue Location||Ubiquitously expressed with strongest expression in skeletal muscle|
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Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Virbasius C.A.,et al.Genes Dev. 7:2431-2445(1993).
Efiok B.J.S.,et al.J. Biol. Chem. 269:18921-18930(1994).
Gopalakrishnan L.,et al.J. Biol. Chem. 270:18019-18025(1995).
Yang S.J.,et al.Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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