Register or Login
All
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DR5 Antibody   

DR5 Antibody

Purified Mouse Monoclonal Antibody (Mab)

     
  • WB - DR5 Antibody AP52788
    Western blot detection of DR5 in SW480,K562,HCT116 and Hela cell lysates using DR5 mouse mAb (1:1000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O14763
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Calculated MW 40,48 KDa
Additional Information
Gene ID 8795
Other Names Fas like protein ;Apoptosis inducing protein TRICK2A/2B ;Apoptosis inducing receptor TRAIL R2 ;CD 262 ;CD262 ;CD262 antigen ;Cytotoxic TRAIL receptor 2 ;Death domain containing receptor for TRAIL/Apo 2L ;Death domain containing receptor for TRAIL/Apo2L ;Death receptor 5 ;DR 5 ;DR5 ;Fas like protein precursor ;KILLER ;KILLER/DR5 ;OTTHUMP00000123492 ;OTTHUMP00000123493 ;p53 regulated DNA damage inducible cell death receptor (killer) ;p53 regulated DNA damage inducible cell death receptor(killer) ;TNF related apoptosis inducing ligand receptor 2 ;TNF related apoptosis inducing ligand receptor 2 ;TNF-related apoptosis-inducing ligand receptor 2 ;TNFRSF10B ;TR10B_HUMAN ;TRAIL R2 ;TRAIL receptor 2 ;TRAIL-R2 ;TRAILR2 ;TRANCER ;TRICK2 ;TRICK2A ;TRICK2B ;TRICKB ;Tumor necrosis factor receptor like protein ZTNFR9 ;Tumor necrosis factor receptor like protein ZTNFR9 ;Tumor necrosis factor receptor superfamily member 10b ;Tumor necrosis factor receptor superfamily, member 10b ;ZTNFR9
Dilution WB~~1:1000
Format Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TNFRSF10B
Synonyms DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to
info@abgent.com, and receive a free "I Love Antibodies" mug.

Background

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.

References

Screaton G.R.,et al.Curr. Biol. 7:693-696(1997).
Walczak H.,et al.EMBO J. 16:5386-5397(1997).
Schneider P.,et al.FEBS Lett. 416:329-334(1997).
Chaudhary P.M.,et al.Immunity 7:821-830(1997).
MacFarlane M.,et al.J. Biol. Chem. 272:25417-25420(1997).

FeedBack
Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at tech@abgent.com.

$ 295.00
Cat# AP52788
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanKoreaLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Buy Antibody, Get One  Selected Loading Control Free.
30% off on 400+ Stem Cells Antibodies. PromoCode: <span class=text-red>FLASH19</span>
Terms & Conditions