|Application ||WB, ICC|
|Calculated MW||26 KDa|
|Other Names||NOG;NOGG_HUMAN;Noggin;SYM 1;SYM1;Symphalangism 1 (proximal);Synostoses (multiple) syndrome 1;SYNS 1;SYNS1.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
Valenzuela D.M.,et al.J. Neurosci. 15:6077-6084(1995).
Groppe J.,et al.Nature 420:636-642(2002).
Gong Y.,et al.Nat. Genet. 21:302-304(1999).
Takahashi T.,et al.Clin. Genet. 60:447-451(2001).
Dixon M.E.,et al.Genet. Med. 3:349-353(2001).
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