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ABAT Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP5316c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP5316c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABAT Antibody (Center) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P80404 |
| Other Accession | P50554, P80147, P61922, Q9BGI0, NP_065737.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Pig, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 56439 Da |
ABAT Antibody (Center) - Additional info | |
| Gene ID 18 | |
| Other Names ABAT; GABAT; 4-aminobutyrate aminotransferase, mitochondrial; (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; Gamma-amino-N-butyrate transaminase; L-AIBAT | |
| Target/Specificity This ABAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-314 amino acids from the Central region of human ABAT. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABAT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABAT Antibody (Center) - Protein Information | |
| Name ABAT | |
| Synonyms GABAT | |
| Function Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | |
| Cellular Location Mitochondrion matrix. | |
| Tissue Location Liver > pancreas > brain > kidney > heart > placenta | |
ABAT Antibody (Center) - Related products
AP5316c: ABAT Antibody (Center)
DC06244: Human ABAT cDNA Clone
ABAT Antibody (Center) - Application data
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ABAT Antibody (Center) (Cat. #AP5316c) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the ABAT antibody detected ABAT protein (arrow).
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ABAT Antibody (Center) (Cat. #AP5316c) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABAT Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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ABAT Antibody (Center) (Cat. #AP5316c) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ABAT Antibody (Center) - Research Areas
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BACKGROUND
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.
REFERENCES
Chakrabarti, B., et al. Autism Res 2(3):157-177(2009) Inada, T., et al. Pharmacogenet. Genomics 18(4):317-323(2008) Wu, C., et al. Proteomics 7(11):1775-1785(2007)
