GBP4 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q96PP9 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 73 KDa |
Antigen Region | 556-595aa |
Gene ID | 115361 |
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Other Names | Guanylate-binding protein 4, GTP-binding protein 4, GBP-4, Guanine nucleotide-binding protein 4, GBP4 |
Dilution | WB~~ 1:1000 |
Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | GBP4 {ECO:0000303|Ref.1, ECO:0000312|HGNC:HGNC:20480} |
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Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity). |
Cellular Location | Golgi apparatus membrane. Cytoplasm Nucleus. Cytoplasm, perinuclear region. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
References
Avdalovic A.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Jikuya H.,et al.DNA Res. 10:49-57(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tripal P.,et al.J. Interferon Cytokine Res. 27:44-52(2007).
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