|Calculated MW||140 KDa|
|Antigen Region||1187-1236 aa|
|Format||Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Epithelial tissues and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Kraus M.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197(1989).
Plowman G.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909(1990).
Katoh M.,et al.Biochem. Biophys. Res. Commun. 192:1189-1197(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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