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Anti-Jak1 Antibody

Mouse Anti Human Monoclonal Antibody

     
  • IP - Anti-Jak1 Antibody AP53401
    Immunoprecipitation analysis of Hela cell lysates using Jak1 mouse mAb.
    detail
  • WB - Anti-Jak1 Antibody AP53401
    Western blot analysis of extracts from C6,Ramos,Jurkat and Hela cell lysates using Jak1 mouse mAb (1:1000 diluted).Predicted band size:130KDa.Observed band size:130KDa.
    detail
  • ICC - Anti-Jak1 Antibody AP53401
    Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using anti-Jak1 mouse mAb (dilution 1:200).
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, IP
Primary Accession P23458
Other Accession NM_002227
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Immunogen Purified recombinant human Jak1 protein fragments expressed in E.coli.
Purification Ammonium sulfate precipitation
Calculated MW 130 KDa
Additional Information
Gene ID 3716
Other Names JAK 1; JAK 1A; JAK 1B; JAK-1; JAK1; JAK1_HUMAN; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; Tyrosine-protein kinase JAK1.
Dilution WB~~1:1000
ICC~~1:200
Format PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol.
Storage Store at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name JAK1
Synonyms JAK1A, JAK1B
Function Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:8232552, PubMed:7615558, PubMed:28111307, PubMed:32750333, PubMed:16239216). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:8232552, PubMed:16239216, PubMed:32750333).
Cellular Location Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated
Tissue Location Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue
Research Areas
Citations (0)
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Background

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

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$ 360.00
Cat# AP53401
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