|Immunogen||Purified recombinant human Toll-like Receptor protein fragments expressed in E.coli.|
|Calculated MW||120922 Da|
|Other Names||PRO285; TLR 7; Tlr7; TLR7_HUMAN ; Toll like receptor 7 ; Toll-like receptor 7; UNQ248.|
|Format||PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist|
|Tissue Location||Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells|
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Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-st
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