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> home > Products > Primary Antibodies > Antibody Collections > Toll receptor signaling > Anti-TAB1 Antibody
Anti-TAB1 Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q15750 |
| Other Accession | NM_006116 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | lgG2b |
| Immunogen | Purified recombinant human TAB1 protein expressed in E.coli. |
| Purification | Affinity purified |
| Calculated MW | 60kDa |
| Gene ID | 10454 |
|---|---|
| Other Names | 2310012M03Rik;3'-Tab1;MAP3K7IP1;MAP3K7IP1;MGC57664;Mitogenactivatedproteinkinasekinasekinase7interactingprotein1;Mitogen-activatedproteinkinasekinasekinase7-interactingprotein1;TAB1;TAB1;TAB1_HUMAN;TAK1bindingprotein1;TAK1-bindingprotein1;TGFbetaactivatedkinase1bindingprotein1;TGF-betaactivatedkinase1/MAP3K7bindingprotein1;TGF-beta-activatedkinase1andMAP3K7-bindingprotein1;TGF-beta-activatedkinase1-bindingprotein1;Transforminggrowthfactorbetaactivatedkinasebindingprotein1. |
| Dilution | WB~~1:1000 |
| Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TAB1 |
|---|---|
| Synonyms | MAP3K7IP1 |
| Function | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Plays also a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). |
| Cellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the endoplasmic reticulum following interaction with STING1 |
| Tissue Location | Ubiquitous.. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
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$ 360.00
Cat# AP53465
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