|Immunogen||Purified recombinant human Met protein expressed in E.coli.|
|Other Names||AUTS9;c met;D249;Hepatocyte growth factor receptor;HGF;HGF receptor;HGF/SF receptor;HGFR;MET;Met proto oncogene tyrosine kinase;MET proto oncogene, receptor tyrosine kinase;Met proto-oncogene (hepatocyte growth factor receptor);Met proto-oncogene;Met protooncogene;MET_HUMAN;Oncogene MET;Par4;Proto-oncogene c-Met;RCCP2;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met.|
|Format||Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain|
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Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
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