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KLC3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q6P597 |
| Other Accession | Q2TBQ9, NP_803136.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55364 Da |
| Antigen Region | 245-274 aa |
| Gene ID | 147700 |
|---|---|
| Other Names | Kinesin light chain 3, KLC2-like, kinesin light chain 2, KLC3, KLC2, KLC2L |
| Target/Specificity | This KLC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the Central region of human KLC3. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLC3 |
|---|---|
| Synonyms | KLC2, KLC2L |
| Function | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity). May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q68G30, ECO:0000250|UniProtKB:Q91W40} Mitochondrion {ECO:0000250|UniProtKB:Q91W40}. Note=In elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria. Also localizes to the manchette in elongating spermatids. {ECO:0000250|UniProtKB:Q68G30, ECO:0000250|UniProtKB:Q91W40} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KLC3 encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.
References
Zhang, Y., et al. Dev. Biol. 275(1):23-33(2004)
Bhullar, B., et al. J. Biol. Chem. 278(18):16159-16168(2003)
Junco, A., et al. Biol. Reprod. 64(5):1320-1330(2001)
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