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ANKRD32 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9BQI6 |
| Other Accession | NP_115666.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 121050 Da |
| Antigen Region | 159-188 aa |
| Gene ID | 84250 |
|---|---|
| Other Names | Ankyrin repeat domain-containing protein 32, BRCT domain-containing protein 1, ANKRD32, BRCTD1 |
| Target/Specificity | This ANKRD32 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-188 amino acids from the N-terminal region of human ANKRD32. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ANKRD32 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLF1 {ECO:0000303|PubMed:25931565, ECO:0000312|HGNC:HGNC:25408} |
|---|---|
| Function | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565, PubMed:36373674). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q8R3P9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8R3P9} Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565) {ECO:0000250|UniProtKB:Q8R3P9, ECO:0000269|PubMed:25931565} |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Adams, D.J., et al. Mol. Cell. Biol. 25(2):779-788(2005)
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$ 182.50
$ 70.00
Cat# AP5407a
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