|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8BZ00, NP_775924.1|
|Calculated MW||72565 Da|
|Antigen Region||551-579 aa|
|Other Names||Sodium/hydrogen exchanger 9, Na(+)/H(+) exchanger 9, NHE-9, Solute carrier family 9 member 9, SLC9A9, NHE9|
|Target/Specificity||This SLC9A9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human SLC9A9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC9A9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.|
|Cellular Location||Late endosome membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a sodium hydrogen exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Defects in this gene are associated with attention-deficit/hyperactivity disorder.
Markunas, C.A., et al. Psychiatr. Genet. (2009) In press :
Vink, J.M., et al. Am. J. Hum. Genet. 84(3):367-379(2009)
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1355-1358 (2008) :
Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :
Ng, D., et al. Int. J. Cancer 123(7):1610-1615(2008)
Levy, D., et al. BMC Med. Genet. 8 SUPPL 1, S3 (2007) :
Nakamura, N., et al. J. Biol. Chem. 280(2):1561-1572(2005)
de Silva, M.G., et al. J. Med. Genet. 40(10):733-740(2003)
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