|Application ||WB, E|
|Other Accession||NP_001158195.1, NP_000943.1, NP_001158194.1, NP_001158193.1|
|Calculated MW||39203 Da|
|Antigen Region||286-312 aa|
|Other Names||Platelet-activating factor receptor, PAF-R, PAFr, PTAFR, PAFR|
|Target/Specificity||This PTAFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-312 amino acids from the C-terminal region of human PTAFR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTAFR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.|
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Provided below are standard protocols that you may find useful for product applications.
PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
Davila, S., et al. Genes Immun. (2010) In press :
Hirota, N., et al. J. Biol. Chem. 285(8):5931-5940(2010)
Kaneko, K., et al. J. Invest. Dermatol. 129(11):2567-2573(2009)
Melnikova, V.O., et al. J. Biol. Chem. 284(42):28845-28855(2009)
Poisson, C., et al. J. Immunol. 183(4):2747-2757(2009)
Sugimoto, T., et al. Biochem. Biophys. Res. Commun. 189(2):617-624(1992)
Seyfried, C.E., et al. Genomics 13(3):832-834(1992)
Kunz, D., et al. J. Biol. Chem. 267(13):9101-9106(1992)
Shukla, S.D. FASEB J. 6(6):2296-2301(1992)
Ye, R.D., et al. Biochem. Biophys. Res. Commun. 180(1):105-111(1991)
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