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PTAFR Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PTAFR Antibody (C-term) AP5414b
    Anti-PTAFR Antibody (C-term) at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • WB - PTAFR Antibody (C-term) AP5414b
    PTAFR Antibody (C-term)(Cat. #AP5414b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PTAFR antibody detected PTAFR protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P25105
Other Accession NP_001158195.1, NP_000943.1, NP_001158194.1, NP_001158193.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 39203 Da
Antigen Region 286-312 aa
Additional Information
Gene ID 5724
Other Names Platelet-activating factor receptor, PAF-R, PAFr, PTAFR, PAFR
Target/Specificity This PTAFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-312 amino acids from the C-terminal region of human PTAFR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTAFR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTAFR
Synonyms PAFR
Function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes.
Research Areas
Citations (0)
citation

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Background

PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.

References

Davila, S., et al. Genes Immun. (2010) In press :
Hirota, N., et al. J. Biol. Chem. 285(8):5931-5940(2010)
Kaneko, K., et al. J. Invest. Dermatol. 129(11):2567-2573(2009)
Melnikova, V.O., et al. J. Biol. Chem. 284(42):28845-28855(2009)
Poisson, C., et al. J. Immunol. 183(4):2747-2757(2009)
Sugimoto, T., et al. Biochem. Biophys. Res. Commun. 189(2):617-624(1992)
Seyfried, C.E., et al. Genomics 13(3):832-834(1992)
Kunz, D., et al. J. Biol. Chem. 267(13):9101-9106(1992)
Shukla, S.D. FASEB J. 6(6):2296-2301(1992)
Ye, R.D., et al. Biochem. Biophys. Res. Commun. 180(1):105-111(1991)

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$ 365.00
$ 140.00
Cat# AP5414b
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