CNNM4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q6P4Q7 |
Other Accession | NP_064569.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 86607 Da |
Antigen Region | 565-593 aa |
Gene ID | 26504 |
---|---|
Other Names | Metal transporter CNNM4, Ancient conserved domain-containing protein 4, Cyclin-M4, CNNM4, ACDP4, KIAA1592 |
Target/Specificity | This CNNM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 565-593 amino acids from the Central region of human CNNM4. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CNNM4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNNM4 |
---|---|
Synonyms | ACDP4, KIAA1592 |
Function | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed. Highly expressed in heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq].
References
Polok, B., et al. Am. J. Hum. Genet. 84(2):259-265(2009)
Parry, D.A., et al. Am. J. Hum. Genet. 84(2):266-273(2009)
Guo, D., et al. Mol Pain 1, 15 (2005) :
Michaelides, M., et al. J. Med. Genet. 41(6):468-473(2004)
Wang, C.Y., et al. Gene 306, 37-44 (2003) :
Downey, L.M., et al. Eur. J. Hum. Genet. 10(12):865-869(2002)
Jalili, I.K., et al. J. Med. Genet. 25(11):738-740(1988)
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