|Application ||WB, IHC-P, E|
|Calculated MW||86607 Da|
|Antigen Region||565-593 aa|
|Other Names||Metal transporter CNNM4, Ancient conserved domain-containing protein 4, Cyclin-M4, CNNM4, ACDP4, KIAA1592|
|Target/Specificity||This CNNM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 565-593 amino acids from the Central region of human CNNM4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNNM4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. Highly expressed in heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq].
Polok, B., et al. Am. J. Hum. Genet. 84(2):259-265(2009)
Parry, D.A., et al. Am. J. Hum. Genet. 84(2):266-273(2009)
Guo, D., et al. Mol Pain 1, 15 (2005) :
Michaelides, M., et al. J. Med. Genet. 41(6):468-473(2004)
Wang, C.Y., et al. Gene 306, 37-44 (2003) :
Downey, L.M., et al. Eur. J. Hum. Genet. 10(12):865-869(2002)
Jalili, I.K., et al. J. Med. Genet. 25(11):738-740(1988)
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