|Application ||WB, IHC-P, E|
|Other Accession||NP_001107592.1, NP_060249.2|
|Calculated MW||92960 Da|
|Antigen Region||10-38 aa|
|Other Names||DEP domain-containing protein 1A, DEPDC1, DEPDC1A|
|Target/Specificity||This DEPDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the N-terminal region of human DEPDC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DEPDC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.|
|Cellular Location||Nucleus. Note=Colocalizes with ZNF224 at the nucleus|
|Tissue Location||Expressed in testis. Up-regulated in bladder cancer cells (at protein level).|
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Kanehira, M., et al. Oncogene 26(44):6448-6455(2007)
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