|Application ||WB, E|
|Other Accession||P58270, NP_036206.3|
|Calculated MW||43084 Da|
|Antigen Region||143-171 aa|
|Other Names||Zinc finger protein DPF3, BRG1-associated factor 45C, BAF45C, Zinc finger protein cer-d4, DPF3, BAF45C, CERD4|
|Target/Specificity||This DPF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the Central region of human DPF3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.|
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Provided below are standard protocols that you may find useful for product applications.
Lange, M., et al. Genes Dev. 22(17):2370-2384(2008)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Hoyal, C.R., et al. J Carcinog 4, 13 (2005) :
Ninkina, N.N., et al. Mamm. Genome 12(11):862-866(2001)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
Chestkov, A.V., et al. Genomics 36(1):174-177(1996)
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