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SHCBP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q8NEM2 |
| Other Accession | Q9Z179, NP_079021.3 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 75690 Da |
| Antigen Region | 500-528 aa |
| Gene ID | 79801 |
|---|---|
| Other Names | SHC SH2 domain-binding protein 1, SHCBP1 |
| Target/Specificity | This SHCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-528 amino acids from the C-terminal region of human SHCBP1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SHCBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SHCBP1 |
|---|---|
| Function | May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. |
| Cellular Location | Midbody. Cytoplasm, cytoskeleton, spindle. Note=Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis |
Provided below are standard protocols that you may find useful for product applications.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Obuse, C., et al. Genes Cells 9(2):105-120(2004)
Schmandt, R., et al. Oncogene 18(10):1867-1879(1999)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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