|Application ||WB, IHC-P, FC, E|
|Other Accession||Q9Z179, NP_079021.3|
|Calculated MW||75690 Da|
|Antigen Region||500-528 aa|
|Other Names||SHC SH2 domain-binding protein 1, SHCBP1|
|Target/Specificity||This SHCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-528 amino acids from the C-terminal region of human SHCBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SHCBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.|
|Cellular Location||Midbody. Cytoplasm, cytoskeleton, spindle Note=Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis.|
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Provided below are standard protocols that you may find useful for product applications.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Obuse, C., et al. Genes Cells 9(2):105-120(2004)
Schmandt, R., et al. Oncogene 18(10):1867-1879(1999)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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