|Application ||WB, IHC-P, FC, E|
|Other Accession||P85968, P14332, Q9DCD0, NP_002622.2, P00349|
|Calculated MW||53140 Da|
|Antigen Region||236-265 aa|
|Other Names||6-phosphogluconate dehydrogenase, decarboxylating, PGD, PGDH|
|Target/Specificity||This PGD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-265 amino acids from the Central region of human PGD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PGD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|
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Provided below are standard protocols that you may find useful for product applications.
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Kerimov, B.F. Vopr. Med. Khim. 48(5):490-496(2002)
Rippa, M., et al. Biochim. Biophys. Acta 1429(1):83-92(1998)
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