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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > MTCH2 Antibody (N-term)
MTCH2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9Y6C9 |
| Other Accession | NP_055157.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33331 Da |
| Antigen Region | 75-103 aa |
| Gene ID | 23788 |
|---|---|
| Other Names | Mitochondrial carrier homolog 2, Met-induced mitochondrial protein, MTCH2, MIMP |
| Target/Specificity | This MTCH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-103 amino acids from the N-terminal region of human MTCH2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTCH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTCH2 {ECO:0000303|PubMed:36264797, ECO:0000312|HGNC:HGNC:17587} |
|---|---|
| Function | Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins (PubMed:36264797). Does not mediate insertion of beta-barrel transmembrane proteins (PubMed:36264797). Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The substrate transported is not yet known. It induces mitochondrial depolarization.
References
Ng, M.C., et al. J. Clin. Endocrinol. Metab. (2010)
He, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(2):327-332(2010)
Li, S., et al. Am. J. Clin. Nutr. 91(1):184-190(2010)
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$ 365.00
$ 140.00
Cat# AP5492a
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