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>   home   >   Products   >   Primary Antibodies   >   GLP1 Antibody (Center)   

GLP1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GLP1 Antibody (Center) AP5500c
    GLP1 Antibody (Center) (Cat.#AP5500c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GLP1 antibody detected the GLP1 protein (arrow).
  • FC - GLP1 Antibody (Center) AP5500c
    GLP1 Antibody (Center) (Cat. #AP5500c) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P0C6A0
Other Accession NP_001096637.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 85-112 aa
Additional Information
Other Names GATA-type zinc finger protein 1, GATA-like protein 1, GLP-1, ZGLP1, GLP1
Target/Specificity This GLP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the Central region of human GLP1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGLP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZGLP1
Synonyms GLP1
Function Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity).
Cellular Location Nucleus. EMBL; AK096830; -; NOT_ANNOTATED_CDS; mRNA EMBL; AC011511; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC044225; -; NOT_ANNOTATED_CDS; mRNA CCDS; CCDS45959.1; - RefSeq; NP_001096637.1; NM_001103167.1 UniGene; Hs.709296; - ProteinModelPortal; P0C6A0; - SMR; P0C6A0; - IntAct; P0C6A0; 1 STRING; 9606.ENSP00000384434; - iPTMnet; P0C6A0; - PhosphoSitePlus; P0C6A0; - BioMuta; ZGLP1; - DMDM; 166990464; - PaxDb; P0C6A0; - PeptideAtlas; P0C6A0; - PRIDE; P0C6A0; - ProteomicsDB; 52325; - Ensembl; ENST00000403903; ENSP00000384434; ENSG00000220201 GeneID; 100125288; - KEGG; hsa:100125288; - UCSC; uc002mnw.5; human CTD; 100125288; - DisGeNET; 100125288; - EuPathDB; HostDB:ENSG00000220201.7; - GeneCards; ZGLP1; - HGNC; HGNC:37245; ZGLP1 HPA; HPA049855; - MIM; 611639; gene neXtProt; NX_P0C6A0; - OpenTargets; ENSG00000220201; - PharmGKB; PA165394820; - eggNOG; KOG1601; Eukaryota eggNOG; COG5641; LUCA GeneTree; ENSGT00470000042444; - HOGENOM; HOG000074114; - HOVERGEN; HBG107952; - InParanoid; P0C6A0; - KO; K21630; - OMA; VQPKRLC; - OrthoDB; EOG091G0O9L; - PhylomeDB; P0C6A0; - ChiTaRS; ZGLP1; human GenomeRNAi; 100125288; - PRO; PR:P0C6A0; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000220201; - ExpressionAtlas; P0C6A0; baseline and differential Genevisible; P0C6A0; HS GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0005667; C:transcription factor complex; IBA:GO_Central GO; GO:0003682; F:chromatin binding; IBA:GO_Central GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001085; F:RNA polymerase II transcription factor binding; IBA:GO_Central GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central GO; GO:0008270; F:zinc ion binding; IEA:InterPro GO; GO:0030154; P:cell differentiation; IBA:GO_Central GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl GO; GO:0048599; P:oocyte development; IEA:Ensembl GO; GO:0007283; P:spermatogenesis; IEA:Ensembl Gene3D; 3.30.50.10; -; 1 InterPro; IPR039355; Transcription_factor_GATA InterPro; IPR000679; Znf_GATA InterPro; IPR013088; Znf_NHR/GATA PANTHER; PTHR10071; PTHR10071; 1 Pfam; PF00320; GATA; 1 PRINTS; PR00619; GATAZNFINGER SMART; SM00401; ZnF_GATA; 1 PROSITE; PS50114; GATA_ZN_FINGER_2; 1 2: Evidence at transcript level; Complete proteome; Developmental protein; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger CHAIN 1 271 GATA-type zinc finger protein 1 /FTId=PRO_0000317557 ZN_FING 206 230 GATA-type. {ECO:0000255|PROSITE- ProRule:PRU00094} SEQUENCE 271 AA; 29628 MW; 7F15849AA6E74732 CRC64; MTEPQVGCVA CPRVHKEPAQ VGTPWPAKPR SHPRKRDPTA LLPRSLWPAC QESVTALCFL QETVERLGQS PAQDTPVLGP CWDPMALGTQ GRLLLDRDSK DTQTRISQKG RRLQPPGTPS APPQRRPRKQ LNPCRGTERV DPGFEGVTLK FQIKPDSSLQ IIPTYSLPCS SRSQESPADA VGGPAAHPGG TEAHSAGSEA LEPRRCASCR TQRTPLWRDA EDGTPLCNAC GIRYKKYGTR CSSCWLVPRK NVQPKRLCGR CGVSLDPIQE G
Citations (0)

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Background

Glucagon is initially synthesised as proglucagon, which is 180 amino acids in length and is cleaved proteolytically. It contains a region corresponding to Glucagon itself, in addition to a signal peptide, spacer regions and two Glucagon-like peptide sequences. GLP1 is encoded by the fourth exon of the six in the human Glucagon gene. It is 37 amino acids in length and has 48% amino acid sequence homology to Glucagon, and is thought to have arisen by gene duplication. The sequence of GLP1 is conserved across many species, however, indicating that it has a particular function. GLP1 is a potent insulin secretagogue, renders pancreatic beta cells 'glucose-competent' and may be useful in the treatment of diabetes mellitus.

References

Sanz, C., et al. Am. J. Physiol. Endocrinol. Metab. 298 (3), E634-E643 (2010) :
Brown, R.J., et al. Diabetes Care 32(12):2184-2186(2009)
Li, S., et al. Dev. Biol. 301(1):106-116(2007)

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Cat# AP5500c
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