- CITATIONS: 1
|Application ||WB, FC, E|
|Calculated MW||42577 Da|
|Antigen Region||243-271 aa|
|Other Names||Krueppel-like factor 17, Zinc finger protein 393, KLF17, ZNF393|
|Target/Specificity||This KLF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids of human KLF17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLF17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).|
Provided below are standard protocols that you may find useful for product applications.
KLF17 binds G/C-rich sites via its zinc fingers and activates transcription from CACCC-box elements. It may be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
Gumireddy, K., et al. Nat. Cell Biol. 11(11):1297-1304(2009) van Vliet, J., et al. Genomics 87(4):474-482(2006) Yan, W., et al. Mech. Dev. 118 (1-2), 233-239 (2002)
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