|Application ||WB, FC, E|
|Calculated MW||56798 Da|
|Antigen Region||495-523 aa|
|Other Names||Asc-type amino acid transporter 1, Asc-1, Solute carrier family 7 member 10, SLC7A10, ASC1|
|Target/Specificity||This AAA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-523 amino acids from the C-terminal region of human AAA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AAA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).
Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Xu, D., et al. Mol. Cell Proteomics 4(8):1061-1071(2005)
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