|Application ||WB, FC, E|
|Calculated MW||56798 Da|
|Antigen Region||495-523 aa|
|Other Names||Asc-type amino acid transporter 1, Asc-1, Solute carrier family 7 member 10, SLC7A10, ASC1|
|Target/Specificity||This AAA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-523 amino acids from the C-terminal region of human AAA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AAA1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).
Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Xu, D., et al. Mol. Cell Proteomics 4(8):1061-1071(2005)
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