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MEIS2 Antibody (Center D269)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP5518c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP5518c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
MEIS2 Antibody (Center D269) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | O14770 |
| Other Accession | P97367, NP_733775 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 51790 Da |
MEIS2 Antibody (Center D269) - Additional info | |
| Gene ID 4212 | |
| Other Names MEIS2; MRG1; Homeobox protein Meis2; Meis1-related protein 1 | |
| Target/Specificity This MEIS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the Central region of human MEIS2. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions MEIS2 Antibody (Center D269) is for research use only and not for use in diagnostic or therapeutic procedures. | |
MEIS2 Antibody (Center D269) - Protein Information | |
| Name MEIS2 | |
| Synonyms MRG1 | |
| Function Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription | |
| Cellular Location Nucleus (By similarity). | |
| Tissue Location Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen | |
MEIS2 Antibody (Center D269) - Related products
AP5518c: MEIS2 Antibody (Center D269)
RI13277: MEIS2 predesign siRNA
DC00713: Human MEIS2 cDNA Clone
LY12880a: MEIS2 Over-expression Lysate
BP5518c: MEIS2 Antibody (Center D269) Blocking peptide
MEIS2 Antibody (Center D269) - Application data
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MEIS2 Antibody (Center D269) (Cat. #AP5518c) western blot analysis in WiDr cell line lysates (15ug/lane).This demonstrates the MEIS2 antibody detected the MEIS2 protein (arrow).
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MEIS2 Antibody (Center D269) (Cat. #AP5518c) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MEIS2 Antibody (Center D269) for immunohistochemistry. Clinical relevance has not been evaluated.
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MEIS2 Antibody (Center D269) (Cat. #AP5518c) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
MEIS2 Antibody (Center D269) - Research Areas
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BACKGROUND
MEIS2 is a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs.
REFERENCES
Adkins, D.E., et al. Mol. Psychiatry (2010) Milech, N., et al. Leuk. Res. 34(3):358-363(2010) Vasan, R.S., et al. JAMA 302(2):168-178(2009) Steelman, S., et al. Genome Res. 7(2):142-156(1997)
