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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   MEIS2 Antibody (Center D269)   

MEIS2 Antibody (Center D269)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MEIS2 Antibody (Center D269) AP5518c
    MEIS2 Antibody (Center D269) (Cat. #AP5518c) western blot analysis in WiDr cell line lysates (15ug/lane).This demonstrates the MEIS2 antibody detected the MEIS2 protein (arrow).
  • IHC - MEIS2 Antibody (Center D269) AP5518c
    MEIS2 Antibody (Center D269) (Cat. #AP5518c) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MEIS2 Antibody (Center D269) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - MEIS2 Antibody (Center D269) AP5518c
    MEIS2 Antibody (Center D269) (Cat. #AP5518c) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
ApplicationWB, IHC, FC, E
Primary AccessionO14770
Other AccessionP97367, NP_733775
ReactivityHuman
PredictedMouse
HostRabbit
ClonalityPolyclonal
IsotypeRabbit Ig
Calculated MW51790 Da
Antigen Region254-280 aa
Additional Information
Gene ID4212
Other NamesHomeobox protein Meis2, Meis1-related protein 1, MEIS2, MRG1
Target/SpecificityThis MEIS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-280 amino acids from the Central region of human MEIS2.
DilutionWB~~1:1000
IHC~~1:50~100
FC~~1:10~50
FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
NameMEIS2
SynonymsMRG1
Function Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.
Cellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue LocationExpressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen
Research Areas
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Background

MEIS2 is a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs.

References

Adkins, D.E., et al. Mol. Psychiatry (2010)
Milech, N., et al. Leuk. Res. 34(3):358-363(2010)
Vasan, R.S., et al. JAMA 302(2):168-178(2009)
Steelman, S., et al. Genome Res. 7(2):142-156(1997)

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$ 265.00
$ 95.00
Cat# AP5518c
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(40 western blots)
Availability: In Stock
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