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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   MEIS2 Antibody (Center D269)   

MEIS2 Antibody (Center D269)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MEIS2 Antibody (Center D269) AP5518c
    MEIS2 Antibody (Center D269) (Cat. #AP5518c) western blot analysis in WiDr cell line lysates (15ug/lane).This demonstrates the MEIS2 antibody detected the MEIS2 protein (arrow).
  • IHC-P - MEIS2 Antibody (Center D269) AP5518c
    MEIS2 Antibody (Center D269) (Cat. #AP5518c) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MEIS2 Antibody (Center D269) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - MEIS2 Antibody (Center D269) AP5518c
    MEIS2 Antibody (Center D269) (Cat. #AP5518c) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession O14770
Other Accession P97367, NP_733775
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51790 Da
Antigen Region 254-280 aa
Additional Information
Gene ID 4212
Other Names Homeobox protein Meis2, Meis1-related protein 1, MEIS2, MRG1
Target/Specificity This MEIS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-280 amino acids from the Central region of human MEIS2.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
Name MEIS2
Synonyms MRG1
Function Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Tissue Location Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen
Research Areas
Citations (0)

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Background

MEIS2 is a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs.

References

Adkins, D.E., et al. Mol. Psychiatry (2010)
Milech, N., et al. Leuk. Res. 34(3):358-363(2010)
Vasan, R.S., et al. JAMA 302(2):168-178(2009)
Steelman, S., et al. Genome Res. 7(2):142-156(1997)

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$ 265.00
$ 95.00
Cat# AP5518c
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(40 western blots)
Availability: In Stock
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