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AHR Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AHR Antibody (Center) AP5533c
    AHR Antibody (Center) (Cat. #AP5533c) western blot analysis in mouse NIH-3T3(lane 1),T47D cell line(lane 2) lysates (35ug/lane).This demonstrates the AHR antibody detected the AHR protein (arrow).
  • IHC-P - AHR Antibody (Center) AP5533c
    AHR Antibody (Center) (Cat. #AP5533c) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AHR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - AHR Antibody (Center) AP5533c
    Confocal immunofluorescent analysis of AHR Antibody (Center)(Cat. #AP5533c) with Hela cell followed by Alexa Fluor搴?488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • FC - AHR Antibody (Center) AP5533c
    AHR Antibody (Center) (Cat. #AP5533c) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35869
Other Accession NP_001612.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 96147 Da
Antigen Region 555-582 aa
Additional Information
Gene ID 196
Other Names Aryl hydrocarbon receptor, Ah receptor, AhR, Class E basic helix-loop-helix protein 76, bHLHe76, AHR, BHLHE76
Target/Specificity This AHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 555-582 amino acids from the Central region of human AHR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAHR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AHR
Synonyms BHLHE76
Function Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
Cellular Location Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus
Tissue Location Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.
Citations (0)

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AHR is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq].


Davila, S., et al. Genes Immun. (2010) In press :
Kalthoff, S., et al. J. Biol. Chem. 285(9):5993-6002(2010)
Hall, J.M., et al. Mol. Endocrinol. 24(2):359-369(2010)
Schroeder, J.C., et al. Biochemistry 49(2):393-400(2010)

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Cat# AP5533c
(40 western blots)
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