|Application ||IF, WB, IHC-P, FC, E|
|Calculated MW||53926 Da|
|Antigen Region||32-61 aa|
|Other Names||Aromatic-L-amino-acid decarboxylase, AADC, DOPA decarboxylase, DDC, DDC, AADC|
|Target/Specificity||This DDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human DDC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDC Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.|
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Provided below are standard protocols that you may find useful for product applications.
This protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency.
Kokkinou, I., et al. J. Neuroimmunol. 216 (1-2), 51-58 (2009) : Meda, S.A., et al. Neuroimage (2009) Ishikawa, S., et al. J. Biol. Chem. 284(42):28832-28844(2009) Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)
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