|Application ||WB, IHC-P, FC, E|
|Other Accession||Q4R7C8, NP_776170.2|
|Calculated MW||15961 Da|
|Antigen Region||14-40 aa|
|Other Names||Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2, Centrosome-associated protein, BLOC1S2, BLOS2, CEAP|
|Target/Specificity||This BLOC1S2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-40 amino acids from the Central region of human BLOC1S2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BLOC1S2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end- directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Lysosome membrane. Note=Localizes to the centrosomes in a microtubule-dependent manner|
|Tissue Location||Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).
Rodriguez-Fernandez, I.A., et al. J. Inherit. Metab. Dis. 32(2):190-203(2009)
Gdynia, G., et al. Apoptosis 13(3):437-447(2008)
Wang, Z., et al. J. Mol. Biol. 343(1):71-82(2004)
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