- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8HYN8, Q64326, NP_000520.1|
|Calculated MW||33927 Da|
|Antigen Region||261-288 aa|
|Other Names||Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, MC2R, ACTHR|
|Target/Specificity||This MC2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-288 amino acids of human MC2R.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MC2R Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Melanocytes and corticoadrenal tissue.|
Provided below are standard protocols that you may find useful for product applications.
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands.
Holliday, K.L., et al. Ann. Rheum. Dis. 69(3):556-560(2010)
Ding, Y.X., et al. Pharmacogenet. Genomics 20(2):71-76(2010)
Roy, S., et al. Endocrinology 151(2):660-670(2010)
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