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MC2R Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MC2R Antibody (C-term) AP5540b
    MC2R Antibody (C-term) (Cat. #AP5540b) western blot analysis in WiDr cell line lysates (15ug/lane).This demonstrates the MC2R antibody detected the MC2R protein (arrow).
  • IHC-P - MC2R Antibody (C-term) AP5540b
    MC2R Antibody (C-term) (Cat. #AP5540b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MC2R Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - MC2R Antibody (C-term) AP5540b
    MC2R Antibody (C-term) (Cat. #AP5540b) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01718
Other Accession Q8HYN8, Q64326, NP_000520.1
Reactivity Human
Predicted Mouse, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33927 Da
Antigen Region 261-288 aa
Additional Information
Gene ID 4158
Other Names Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R, MC2R, ACTHR
Target/Specificity This MC2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-288 amino acids from the C-terminal region of human MC2R.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMC2R Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MC2R
Synonyms ACTHR
Function Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Melanocytes and corticoadrenal tissue.
Research Areas
Citations ( 0 )


MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands.


Holliday, K.L., et al. Ann. Rheum. Dis. 69(3):556-560(2010)
Ding, Y.X., et al. Pharmacogenet. Genomics 20(2):71-76(2010)
Roy, S., et al. Endocrinology 151(2):660-670(2010)

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$ 295.00
$ 99.00
Cat# AP5540b
(40 western blots)
Availability: In Stock
Bulk Size
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